The science behind Restylane® Skinboosters™
Science behind
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The science behind Restylane® Skinboosters™

Restylane® SKINBOOSTERS™ is the original and only hyaluronic acid skin quality treatment clinically proven to enhance 6 key aspects of 
skin quality while providing deep hydration – with results that last up 
to 15 months.1–14

Glow through life with the most 
natural solution

Glow through life with the most
natural solution

Hyaluronic acid is a natural molecule in our bodies that can bind huge amounts of water and keeps our body tissues hydrated, soft and flexible. From the age of 28, we lose around 1% per year of the hyaluronic acid in our skin, leading to a dry, dull and wrinkled appearance.32-34

The closest to your skin’s own composition

Restylane® SKINBOOSTERS™ contains stabilized hyaluronic acid that is the closest to your skin’s naturally occurring hyaluronic acid.15-19

Clinically proven to boost skin quality

Restylane® SKINBOOSTERS™ can help you achieve smooth, even, younger-looking skin with a fresh, natural and healthy glow.1,4,8-12

Fast-acting for immediate deep hydration

Restylane® SKINBOOSTERS™ uses the natural ability of hyaluronic acid to bind water molecules, locking moisture within the skin.4,17,21-24

Longest lasting with unmatched results

Compared with other hyaluronic acid skin quality treatments, Restylane® SKINBOOSTERS™ offers the longest duration of skin quality improvements of up to 15 months.1

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Most versatile skin quality boosting treatment available

With a collection of two products formulated for every skin type and skin tone, as well as diverse treatment areas, Restylane® SKINBOOSTERS™ is for individuals concerned about skin quality and desiring smooth, hydrated, younger-looking, glowing skin without changing their facial shape.25-27

With Restylane® SKINBOOSTERS™ VITAL, address areas with regular to thicker skin like the midface, cheeks, hands and decolletage. For thinner more delicate areas, like around the mouth, eyes and neck, go with Restylane® SKINBOOSTERS™ VITAL LIGHT for a more delicate touch.26

Most versatile skin quality boosting treatment available
Most versatile skin quality boosting treatment available

With a collection of two products formulated for every skin type and skin tone, as well as diverse treatment areas, Restylane® SKINBOOSTERS™ is for individuals concerned about skin quality and desiring smooth, hydrated, younger-looking, glowing skin without changing their facial shape.25-27

With Restylane® SKINBOOSTERS™ VITAL, address areas with regular to thicker skin like the midface, cheeks, hands and decolletage. For thinner more delicate areas, like around the mouth, eyes and neck, go with Restylane® SKINBOOSTERS™ VITAL LIGHT for a more delicate touch.26

Restoring hydration and skin 
quality from within

Restoring hydration and skin
quality from within

Natural hyaluronic acid in our bodies forms long molecular chains. This naturally occurring hyaluronic acid forms and degrades quickly in 24-48 hours. Restylane® SKINBOOSTERS™ provides a unique skin quality-enhancing effect based on the small particle and high molecular weight SB-NASHA™ technology, closely mimicking natural hyaluronic acid but with long-lasting effects.

 

By injecting precise microdroplets deep into the dermis, Restylane® SKINBOOSTERS™ creates an immediate hydration boost and mechanical stimulation. Its unique cross-linking technology allows for long-lasting optimization of the extracellular matrix and cell turnover, helping the skin revitalize from within by boosting its own hyaluronic acid, elastin and collagen quality for enhanced skin health. What’s more, SB-NASHA™ distinctively remains within the dermis longer than non-crosslinked hyaluronic acid technologies, with results lasting up to 15 months.1-14

Award-winning SmartClick™ system

Award-winning SmartClick™ system
 

Restylane® SKINBOOSTERS™ is the only hyaluronic acid skin quality treatment that uses a bespoke, patented SmartClick™ syringe system.
This award-winning system provides audible feedback, allowing for reproducible microdroplet delivery, increasing safe use, and focusing on the injection technique by improving precision and control.14,21,28-31

Backed by science, inspired by you

 

Restylane® products are backed not only by science but also by the professionals and patients who use them. These satisfied individuals motivate us to keep going–to keep innovating and developing aesthetic solutions that deliver the results they’re looking for.

Patients who had global aesthetic improvements8​​
 

0 %

Patients who agree their skin quality improved1
 

0 %
Backed by science, inspired by you
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1. Wu Y et al. J Cosmet Dermatol. 2020;19(7):1627–1635. 2. Williams S et al. J Cosmet Dermatol. 2009;8(3):216–225. 3. Ribé A et al. J Cosmet Laser Ther. 2011;13(4):154–161. 4. Lee BM et al. Arch Plast Surg. 2015;42(3):282–287. 5. Lim H-K et al. J Cosmet Laser Ther. 2014;16(1):32–36. 6. Qian W et al. J Cosmet Dermatol. 2018;17(4):596–599. 7. Kim J. Arch Aesthetic Plast Surg. 2014;20(2):97–103. 8. Gubanova EI et al. Poster presented at IMCAS, Jan–Feb 2015, Paris, France. 9. Gubanova EI et al. J Drugs Dermatol. 2015;14(3):288–299. 10. Dierickx C et al. Dermatol Surg. 2018;44 Suppl 1:S10–S18. 11. Gubanova EI et al. Aesthetic Med. 2010;1:94–98. 12. Data on File. MA-54615. Restylane SKINBOOSTERS Competitor Comparison. Benching document 2022. 13. Kerscher M et al. Dermatol Surg. 2008;34(5):720–726. 14. Belmontesi M et al. J Drugs Dermatol. 2018;17(1):83–88. 15. Data on File. MA-43602. Clinical evaluation Restylane NASHA fillers MDR. 16. Verpaele A and Strand A. Aesthet Surg J. 2006;26(1S):S10–S17. 17. Kablik J et al. Dermatol Surg. 2009;35(Suppl 1):302–312. 18. Micheels P et al. J Drugs Dermatol. 2016;15(5):600–606. 19. Edsman K et al. Dermatol Surg. 2012;38(7 Pt 2):1170–1179. 20. Restylane® Injectable Gel. Summary of Safety and Effectiveness Data (SSED). www.accessdata.fda.gov/cdrh_docs/pdf2/P020023b.pdf (accessed December 2022). 21. Nikolis A, Enright KM. J Dermatol Skin Sci. 2020;2(1):26–28. 22. Rogerio V et al. J Stomatol Oral Maxillofac Surg. 2022;123(4):440–447. 23. Tezel A, Fredrickson GH et al. J Cosmet Laser Ther. 2008;10(1):35–42. 24. Rohrich RJ et al. Plast Reconstr Surg. 2007;120(6 Suppl):41S–54S.
25. Restylane SKINBOOSTERS VITAL EU IFU. 2020. 26. Kerscher M et al. Cosmetic Medicine 2.17. Available at: https://plasticna-kirurgija.si/files/static/36 (accessed December 2022).
27. Restylane SKINBOOSTERS VITAL LIGHT EU IFU. 2020. 28. Aesthetics Journal News. Restylane SKINBOOSTERS SmartClick delivery system wins Red Dot Award. Available at: https://aestheticsjournal.com/news/restylane-skinboosters-smartclick-delivery-system-wins-red-dot-award (accessed December 2022). 29. Red Dot Design Award. Injection Device SmartClick™ System. Available at: https://red-dot.org/project/smartclicktm-system-32176 (accessed December 2022). 30. Daoud A and Weiss R. IntechOpen. 2021:1–6. 31. Landau M, Fagien S. Plast Reconstr Surg. 2015;136(5 Suppl.):188S–195S. 32. Koblenzer CS. Clin Dermatol 1996;14(2):171–7. 33. Matsubara et al. Skin Res Technol 2012;18(1):29–35. 34. Finn CJ et al. Dermatol Surg 2003;29(5):450–455.

Always consult a healthcare professional for individualized treatment recommendations and to discuss important safety information and risks associated with the use of the products.