Refine Fill Overview

Why Fill?
Why fill

Why fill with RESTYLANE®

As we age, our skin becomes thinner and less elastic, and its ability to retain water is reduced. The result is the appearance of fine lines and wrinkles, and you may feel that you look tired, old or sad. Treatments with dermal fillers help to restore and maintain your youthful appearance and regain lost confidence.3

RESTYLANE® is a firmer dermal filler that can be used to fill wrinkles where you have good tissue coverage. Restylane® REFYNE™ is a softer and more flexible dermal filler that can be used for treatment of more dynamic areas of your face, for example, around the lips, the nasolabial folds and the marionette lines.4  RESTYLANE® and Restylane® REFYNE™ help you refine your looks and realize your individual needs and desires.

RESTYLANE® and Restylane® REFYNE™ last up to at least 18 months with one retreatment.5

Treatment areas

RESTYLANE® and Restylane® REFYNE™ treatment areas

RESTYLANE® and Restylane® REFYNE™ are dermal fillers that are used to reduce lines and wrinkles and give you a refined and natural look. Areas that can be treated are, for example, fine lines around the mouth and eyes, marionette lines and nasolabial folds. 

“And if you then all of a sudden see how signs of aging, signs of tiredness or negative expressions are erased from your face, that’s a very positive experience and usually you can see this when the patient looks in the mirror. Their face starts smiling, and that is a very rewarding moment really for an aesthetic doctor.”

Christoph Martschin, dermatologist, Sweden

nasolabial folds
Upper lip lines
marionette lines
tear trough
Nasolabial folds
Tear trough
Marionette lines
Upper lip lines
Your treatment
Your treatment

Your Restylane® treatment

A treatment with Restylane® takes approximately 15-45 minutes, depending on the area that will be treated. Sometimes you might need a touch-up treatment about two weeks after the initial treatment to optimize your results. Most Restylane fillers contain a local anesthetic, lidocaine, that takes away most of the discomfort during treatment. 

Immediately after your dermal filler treatment, you may experience some post-treatment side effects, such as redness, swelling, pain, bruising or tenderness at the treatment site. These side effects usually disappear within one week after injection. Though fillers are minimally invasive, they still carry some risks. Before the treatment, you should discuss all possible risks and benefits with your healthcare practitioner.

Restylane® gives you long-lasting but non-permanent results, meaning that you can continuously refine your looks. 

How it works
How it works

How it works

Hyaluronic acid is a substance that has a unique ability to bind water. Hyaluronic acid occurs naturally in our bodies and in all layers of our skin. It keeps your body tissues soft, hydrated and flexible. However, as we age, the body’s ability to produce hyaluronic acid lessens, leading to dry and thinner skin.  

Native hyaluronic acid in the body degrades quickly, in one to two days. To make the hyaluronic acid in RESTYLANE® and Restylane® REFYNE™ last longer—for up to 18 months or more with one retreatment6—Galderma has used stabilization technologies that delay degradation. 
RESTYLANE® contains a hyaluronic acid gel with a firmer consistency and Restylane® REFYNE™ contains a gel with a more flexible consistency to target different kinds of lines and wrinkles. 

RESTYLANE® was the first ever non-animal stabilized hyaluronic acid filler, when it was launched in 1996. It has become the gold standard of dermal fillers and is the injectable filler that every other filler brand is compared with.

Before & After

See how RESTYLANE® and Restylane® REFYNE™ can help.

Before and after

Long-lasting results – up to at least 18 months with one treatment.7

96% of patients thought that their results looked natural8

100% of patients saw improvement in their appearance 1 month after treatment9


A treatment with Restylane does not take long. Depending on the area and indication, it takes approximately 15-45 minutes. A touch-up treatment is sometimes performed approximately two weeks after the initial treatment to optimize the results.

Some people may experience mild discomfort. Most Restylane fillers contain an integrated local anesthetic, lidocaine, to provide you with a more comfortable treatment experience. You and your healthcare practitioner may decide whether additional pain relief is needed.

Ask your healthcare practitioner if you will benefit from treatment with any of the hyaluronic acid products within the Restylane range. It is important when discussing your medical history to tell your practitioner everything, including all medicines that you are taking, any present and past allergies and their seriousness, and all current or past medical conditions you have had. Your practitioner will discuss potential side effects from the injection of Restylane and how serious they may be. You should also inform your practitioner if you have received previous aesthetic treatments, both surgical and non-surgical. 

Patients with a known allergy to hyaluronic acid based products should not undergo treatment, nor should patients with bleeding disorders, or active skin disease such as inflammation, infection or tumors in or near the area to be treated. Discuss contraindications, warnings and precautions with your healthcare practitioner before Restylane filler treatments.

The Restylane products have not been tested in pregnant or breastfeeding women and is therefore not recommended if you are pregnant or breastfeeding.

After the treatment you will receive post-treatment guidelines. It is normal to experience some post-treatment discomfort, such as redness, swelling, pain, itching, bruising or tenderness at the treatment site. These side effects generally disappear within one week after injection.

Other potential side effects can occur with dermal fillers based on hyaluronic acid. You should discuss the potential treatment risks with your healthcare practitioner. Following treatment, there is sometimes a need for a touch-up treatment to achieve an optimal result.

Skin insights

Our portfolio of products

Galderma has developed a diverse portfolio of products that work holistically together.



Relax the tension of facial muscles associated with crow´s feet and frown lines to show how you truly feel inside.



Refresh your skin from within with a boost of deep hydration, for a refreshed and vibrant look that lasts.



Renew the structure of your skin with a collagen activator that gradually builds the foundation of the youthful, firmer you.

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1 Philipp-Dormston WG et al. Dermatol Surg 2018;44(6):826-832.; Weiss RA et al. Dermatol Surg 2016;42:699–709.; Narins RS et al. Dermatol Surg 2011;37:644–650.
2 Talarico S et al. Dermatol Surg 2015;41:1361–1369.; Rzany B et al. Dermatol Surg 2012;38:1153–1161.
3 Talarico S et al. Dermatol Surg 2015;41:1361–1369.; Rzany B et al. Dermatol Surg 2012;38:1153–1161.
4 Philipp-Dormston WG et al. Dermatol Surg 2018;44(6):826-832.
5 Narins RS et al. Dermatol Surg 2008;34:S2–S8.; Rzany B et al. Dermatol Surg 2017;43:58–65.
6 Narins RS et al. Dermatol Surg 2008;34:S2–S8.; Rzany B et al. Dermatol Surg 2017;43:58–65.
7 Rzany B et al. Dermatol Surg 2017;43:58–65.; Narins RS et al. Dermatol Surg 2008;34:S2–S8.
8 Rzany B et al. Dermatol Surg 2012;38:1153–1161.
9 Swift A et al. Clin Cosmet Investig Dermatol 2017;10:229–238.