Why lift with RESTYLANE®?
Our facial bones give shape and structure to our faces. As we age, bone resorption can increase, leading to loss of definition and contours, especially at the posterior part of the jawline. Another consequence of aging is volume loss in the mid-face, which can happen with age, or after rapid weight loss. This can lead to flat cheeks, sagging skin, and jowls.6,7
RESTYLANE® hyaluronic acid injectables can help compensate for these changes by adding volume to your cheeks, sharpening your jawline, and reducing your jowls.4,5 RESTYLANE® can also help if you want to enhance your facial features and can bring out your individuality.

RESTYLANE® treatment areas
Restylane® DEFYNE™ and Restylane® LYFT™ are dermal fillers that give precise results, creating a projection or a lift of the treated area. Areas that can be treated are, for example, the chin, jawline, cheeks and nose bridge.
“I have patients that look the same or better now than they did 15 years ago.” Steven Weiner, Plastic Surgeon, USA

RESTYLANE® treatment areas

Restylane® DEFYNE™ and Restylane® LYFT™ are dermal fillers that give precise results, creating a projection or a lift of the treated area. Areas that can be treated are, for example, the chin, jawline, cheeks and nose bridge.
“I have patients that look the same or better now than they did 15 years ago.” Steven Weiner, Plastic Surgeon, USA
What is Restylane® LYFT™?
Restylane® LYFT™ is a firm injectable gel of hyaluronic acid. This dermal filler is suitable for lifting your cheeks, enhancing your jawline, shaping your chin, and reducing the appearance of jowls and wrinkles. Restylane® LYFT™ provides precise results to the treated area.4
Restylane® LYFT™ for cheeks
Restylane® LYFT™ is a firm injectable, which is ideal as a treatment for providing lift and structure to your cheekbones without volumizing. This can help to give a sharper appearance to your cheeks, providing support and projection where needed, and to rebalance any facial changes following natural aging, or weight loss.2,4,8,9
Restylane® LYFT™ for jaw and chin
Restylane® LYFT™ is well suited for providing projection and structure to your jaw and chin. Your facial muscles are always moving, but as a firm gel, Restylane® LYFT™ has been designed to stay where it has been injected.4,10,11
What is Restylane® DEFYNE™?
Restylane® DEFYNE™ is a hyaluronic acid injectable gel. It is a softer, more flexible dermal filler than Restylane® LYFT™. Restylane® DEFYNE™ delivers precise results, providing a softer projection or lifting to your jawline, chin, and nasolabial folds.5,9,12–17
Restylane® DEFYNE™ has been shown to look natural with your facial expression and can be used to provide soft volume, contouring, and definition.5,12,16,17
Restylane® DEFYNE™ for jaw and chin
Restylane® DEFYNE™ is ideal as a jaw and chin filler because it provides flexible support. Studies have shown that improved chin projection lasts well with just one treatment of Restylane® DEFYNE™.18
How long does Restylane® DEFYNE™ hyaluronic acid injectable last?
Treatments with Restylane® DEFYNE™ can last up to at least 1 year.17
“I have patients that look the same or better now than they did 15 years ago.” Steven Weiner, Plastic Surgeon, USA
Your RESTYLANE® hyaluronic acid injectable treatment
RESTYLANE® dermal filler treatments take approximately 15-45 minutes, depending on the area that will be treated. Sometimes you might need a touch-up treatment about two weeks after the initial treatment to optimize your results. Restylane® DEFYNE™ and Restylane® LYFT™ injectables contain a local anesthetic, lidocaine, that removes most of the discomfort during treatment. 4,5,19
Restylane® DEFYNE™ and Restylane® LYFT™ aftercare
Immediately after your dermal filler treatment, you may experience some post-treatment side effects, such as redness, swelling, pain, bruising, or tenderness at the injection site. These side effects usually disappear up to two weeks after injection.4,5 Though dermal fillers are minimally invasive, they still carry some risks. Before the treatment, discuss all possible risks and benefits with your healthcare practitioner.
RESTYLANE® gives you long-lasting but non-permanent results, which means you can continuously refine your looks.

How RESTYLANE® works
Hyaluronic acid is the main ingredient of RESTYLANE® dermal fillers. Hyaluronic acid is a substance that has a unique ability to bind water. Hyaluronic acid occurs naturally in our bodies and in all layers of our skin. It keeps our body tissues soft, hydrated, and flexible. However, as we age, the body’s ability to produce hyaluronic acid lessens, leading to dry, thinner skin and loss of youthful volume.20
Natural hyaluronic acid in the body degrades quickly, in one to two days. To make the hyaluronic acid in Restylane® DEFYNE™ and Restylane® LYFT™ injectables last longer, Galderma has used stabilization technologies that delay degradation.21 Restylane® DEFYNE™ and Restylane® LYFT™ contain hyaluronic acid gels that provide good support to maintain structure and projection.4,5
RESTYLANE® was the first ever non-animal stabilized hyaluronic acid (NASHA) injectable when it was approved in 1996.22 It is the closest to natural HA technology on the market and has been trusted by healthcare practitioners for over 25 years.22,23
Read more about The Science Behind RESTYLANE®.

Restylane® DEFYNE™ and Restylane® LYFT™ injectables - before and after
View pictures of before and after Restylane® LYFT™ and Restylane® DEFYNE™ hyaluronic acid injectables. See the differences in jaw, chin, and cheeks before and after RESTYLANE® dermal fillers.

96 %
thought Restylane® LYFT™ met
or exceeded expectations1
9 out of 10
patients would have
Restylane® DEFYNE™ again24,25
Over 55 million
aesthetic treatments with
RESTYLANE® since
199622
Frequently asked questions about Restylane® LYFT™ and Restylane® DEFYNE™
What is the difference between Restylane® DEFYNE™ and Restylane® LYFT™?
Restylane® DEFYNE™ is a softer dermal filler than Restylane® LYFT™.
How many syringes of RESTYLANE® would be needed for cheek fillers?
The amount of RESTYLANE® required for cheeks will depend on individual needs. People who want a more defined look will require more filler than those who are looking for a small lift.
Does Restylane® LYFT™ and Restylane® DEFYNE™ injections work for jowls?
Jowls are the result of sagging skin around the jawline and chin, so Restylane® LYFT™ and Restylane® DEFYNE™ can be used in these areas to help reduce the appearance of jowls by sharpening the chin and jawline.
How many syringes of RESTYLANE® would be needed for jowls, jaw, and chin?
The amount of RESTYLANE® required for jowls, jawlines, and chins will depend on individual needs. People who want a more defined jawline and less noticeable jowls look will require more filler than those who are looking for a less impactful difference.
Is Restylane® DEFYNE™ or Restylane® LYFT™ suitable for faces left gaunt after weight loss?
Yes, Restylane® DEFYNE™ and Restylane® LYFT™ injectables can be used to help provide volume to cheeks following rapid weight loss, which can leave cheeks looking hollow and gaunt.
Are hyaluronic acid injections painful?
Some people may experience mild discomfort. Most RESTYLANE® injectables contain an integrated local anesthetic, lidocaine, to provide you with a more comfortable treatment experience. You and your healthcare practitioner may decide whether additional pain relief is needed.
Are you looking for a clinic?
References
- Data on file (MA-39364).
- Weiss RA et al. Dermatol Surg. 2016;42:699–709.
- Narins RS et al. Dermatol Surg. 2011;37:644–50.
- Restylane® LYFT™, Instructions for use, EU.
- Restylane® DEFYNE™, Instructions for use, EU.
- Swift A et al. Aesthet Surg J. 2021;41(10):1107–19.
- Humphrey CD, Lawrence AC. Facial Plast Surg. 2023;39(6):719–21.
- Nikolis A et al. Aesthet Surg J. 2022;42:285–97.
- Di Gregorio C et al. Clin Cosmet Investig Dermatol. 2022;15:681–90.
- Lundgren B et al. J Drugs Dermatol. 2018;17:982–6.
- Data on file (MA-43049).
- Öhrlund JÅ, Edsman KLM. Dermatol Surg. 2015;41(Suppl 1):S358–64.
- Percec I et al. Plast Reconstr Surg. 2020;145:295e–305e.
- Rogerio V et al. J Stomatol Oral Maxillofac Surg. 2022;123:440–7.
- Solish N et al. J Cosmet Dermatol. 2019;18:738–46.
- Philipp-Dormston WG et al. J Cosmet Dermatol. 2020;19:1600–6.
- Ascher B et al. Dermatol Surg. 2017;43:389–95.
- Data on file. 43USCH1702 Clinical Study Report. Galderma Laboratories, L.P., 2020.
- Smith L, Cockerham K. Patient Prefer Adherence. 2011;5:133–9.
- Papakonstantinou E et al. Dermatoendocrinol. 2012;4(3):253–8.
- Kablik J, et al. Dermatol Surg. 2009;35 Suppl 1:302–12.
- Galderma. Data on file. MA-39680.
- Edsman K, et al. Dermatol Surg. 2012;38:1170–9
- Talarico S et al. Dermatol Surg. 2015;41:1361–9.
- Cartier H et al. J Drugs Dermatol. 2012;11(1 Suppl):s17–26.
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